Research Positions
Wnt/beta-catenin signaling in early breast neoplasia
Description
A postdoctoral scientist position is immediately available in the laboratory of Dr. Louise R. Howe at Weill Cornell Medical College. Dr. Howe's group uses a combination of cell biology, molecular biology and whole animal approaches to elucidate the molecular mechanisms underlying the development and growth of breast cancer (http://www.med.cornell.edu/research/lrhowe/). Our goal is to translate this basic biology into novel approaches for breast cancer prevention and treatment. Ongoing research in the lab focuses on the feasibility of preventing breast cancer through targetting the cyclooxygenase-prostaglandin signaling pathway. We are now recruiting a postdoctoral fellow for NIH-funded research into the role and regulation of Wnt/beta-catenin signaling in early breast neoplasia.
Requirements
Candidates demonstrating the ability to be highly motivated, work independently, and with a strong background in molecular and cell biology and tissue culture are encouraged to apply. Experience in cell signalling pathways would also be helpful. Candidates should have received a Ph.D. degree within the last three years. Good organizational skills are desirable, and fluent English is essential. Salary will be commensurate with experience.
Contact Information:
Please send a detailed CV including a brief summary of research experience and interests, and the names and contact details for three references to:
Louise R. Howe, Ph.D.
Department of Cell & Developmental Biology
Weill Cornell Medical College
1300 York Avenue, Box 60
New York, NY 10065
E-mail: lrhowe@med.cornell.edu
Description
The Department of Cell and Developmental Biology is seeking an individual with expertise in transgenic mouse technology. This position in the laboratory of Dr. Katherine Hajjar will be at the Research Associate level. The incumbent will hold a Ph.D., have several years experience in the field, and be responsible for creating and analyzing genetically engineered mice with defects related to the cell surface proteases in vascular biology.
Contact Information:
Katherine A. Hajjar, MD
Department of Cell and Developmental Biology
Weill Cornell Medical College
212-746-2034
http://www.med.cornell.edu/research/kahajjar/
Description
Assistant Research Professor
The successful candidate will assume the role of manager of a sizable (300 cages+) mouse colony.
S/he will be responsible for all aspects of mouse breeding, genotype analysis, phenotype determination, and mouse import/export procedures.
S/he would also implement a computerized inventory system to track the pedigrees of all laboratory animals.
S/he will train postdoctoral fellows and students in mouse colony management, mouse surgical procedures, and analytical tissue techniques.
S/he will write animal research protocols and insure full compliance with federal, state, and local regulations.
Description
Two postdoctoral positions are available immediately to study angiogenesis in mouse models of human tumors.
The research will focus on identifying the molecular mechanisms of tumor angiogenesis, and its component processes including co-option of vascular cells from host blood vessels and recruitment of bone marrow vascular progenitor cells. The work will involve the use of existing mouse genetic models (complete deficiency of annexin 2 and related molecules), development of conditional knockouts, bone marrow transplantation, flow cytometric cell analyses and fractionation, immunohistology, functional analysis of gene-targeted endothelial cells and vascular mural cells, and genomic methods.
Requirements
Candidates should have received a PhD degree within the last three years and have documented experience in molecular biology, with special emphasis on cloning methodologies. Background in vascular development biology and mouse surgical and husbandry skills are highly desirable. Appointments are for one year, with renewal based upon satisfactory performance and funding availability.
Contact Information:
Interested candidates should send a curriculum vitae, brief summary of research interests and experience, and the names and contact information for three references to:
Dr. Katherine A. Hajjar
Department of Cell and Developmental Biology
Weill Cornell Medical College
Email: khajjar@med.cornell.edu
http://www.med.cornell.edu/research/kahajjar/
Self-renewal of cancer stem cells and iPS cells
Description
A postdoctoral position is available immediately to conduct research on the regulation of self-renewal and asymmetric division in cancer stem cells and induced pluripotent stem cells. Specifically, systems will be developed to allow pluripotency and self-renewal to be monitored by live cell imaging. The research is a Tri-Institutional collaborative effort involving the laboratories of Dr. Anthony Brown at Weill Cornell Medical College, Dr. Prasad Jallepalli at the Sloan-Kettering Institute, and Dr. Ali Brivanlou at the Rockefeller University. The postdoc would be based in Dr. Brown’s laboratory and would interact with the other two laboratories, receiving guidance from all three lab heads.
Requirements
Candidates should have received a PhD degree within the last three years and have documented expertise in cell and molecular biology. Experience in stem cell biology is desirable but not essential.
Contact Information:
Interested candidates should send a curriculum vitae, brief summary of research interests and experience, and the names and contact information of three referees to:
Anthony M. C. Brown, PhD
Weill Cornell Research Labs
310 E. 67th Street
New York, NY 10065
Email: amcbrown@med.cornell.edu
http://www.med.cornell.edu/research/amcbrown/
