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Session #1: Introduction to the group |
Date: Thurs, Sept 22, noon - 2PM (moderators: Myat and Sato) |
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| Session #2: Introduction to tube formation and branching morphogenesis |
Date: Thurs, Sept 29, noon - 2PM (moderators: Myat and Sato) |
Reviews:
Hogan, B. L., and Kolodziej, P. A. (2002). Organogenesis: molecular mechanisms of tubulogenesis. Nat Rev Genet 3, 513-523.
Uv A., Cantera R., Samakovlis C. (2003). Drosophila tracheal morphogenesis: intricate cellular solutions to basic plumbing problems?. Trends in Cell Biology, 13, 301-309.
Optional Readings:
Kim HJ, Bar-Sagi D. (2004). Modulation of signalling by Sprouty: a developing story. Nature Reviews Molecular Cell Biology 5, 441-450.
Sudarsan V. (2003). Tube Morphogenesis: No Pipe Dream in Drosophila. Curr Biol. 18, R131-R133.
Denholm B. Shaer H. (2003). Tubulogenesis: a role for the apical extracellular matrix? Curr Biol. 2 R909-R911.
Experimental Papers:
Hacohen N., Kramer S., Sutherland D., Hiromi Y., Krasnow MA. (2003). sprouty Encodes a Novel Antagonist of FGF Signaling that Patterns Apical Branching of the Drosophila Airways. Cell. 1998 23; 253-263.
Jazwinska A., Ribeiro C., Affolter M. (2003). Epithelial tube morphogenesis during Drosophila tracheal development requires Piopio, a luminal ZP protein. Nat Cell Biol. 5(10) 895-901.
Myat, M. M., Andrew DJ. (2005). Epithelial Tube Morphology Is Determined by the Polarized Growth and Delivery of Apical Membrane. Cell. 111, 879-891. |
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| Session #3: Neural Tube Formation |
Date: Thurs, Oct 6, noon - 2PM (moderator: Myat) |
Reviews:
Copp, A. J., Greene, N. D., and Murdoch, J. N. (2003). The genetic basis of mammalian neurulation. Nat Rev Genet 4, 784-793.
Wallingford , J. B. (2005). Neural tube closure and neural tube defects: studies in animal models reveal known knowns and known unknowns. Am J Med Genet C Semin Med Genet 135, 59-68.
Discussion materials:
Haigo, S. L., Hildebrand, J. D., Harland, R. M., and Wallingford, J. B. (2003). Shroom induces apical constriction and is required for hingepoint formation during neural tube closure. Curr Biol 13, 2125-2137.
Lu, X., Borchers, A. G., Jolicoeur, C., Rayburn, H., Baker, J. C., and Tessier-Lavigne, M. (2004). PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates. Nature 430, 93-98.
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| Session #4: Lung and Tracheal Formation |
Date: Thurs, Oct 20, noon - 2PM |
Guest Faculty: Dr. Doris Herzlinger (Department of Physiology and Biophysics, Weill Medical College of Cornell University)
Reviews:
Ghabrial A, Luschnig S, Metzstein MM, Krasnow MA. Branching morphogenesis of the Drosophila tracheal system. Annu. Rev. of Cell and Dev. Biol. 2003; 19:623-647.
Chuang PT, McMahon AP. Branching morphogenesis of the lung: new molecular insights into an old system. Trends in Cell Biol. 2003 Feb; 13(2):86-91.
Primary research Papers:
Sakiyama J, Yamagishi A, Kuroiwa A. Tbx4-Fgf10 system controls lung bud formation during chicken embryonic development. Development. 2003 Arp; 130(7):1225-1234.
Weaver M, Dunn NR, Hogan BL. Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis. Development. 2000 Jun; 127(12):2695-2704.
Ribeiro C, Ebner A, Affolter M. In vivo imaging reveals different cellular functions for FGF and Dpp signaling in tracheal branching morphogenesis. Dev. Cell. 2002 May; 2(5):677-683. |
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| Session #6: Blood Vessel and Heart Formation |
Date: Thurs, Oct 27, noon - 2PM (moderator: Sato) |
Reviews:
Risau, W. (1997). Mechanisms of angiogenesis. Nature 386, 671-674.
Risau, W., and Flamme, I. (1995). Vasculogenesis. Annu Rev Cell Dev Biol 11, 73-91.
T.N.Sato and S. Loughna (2002). "Vasculogenesis and Angiogenesis" In: Mouse Development. (eds. J. Rossant and P.P.L. Tam), Academic Press. Chapter 11, 211-233.
R.P.Harvey (2002). "Molecular Determinants of Cardiac Development and Congenital Disease" In: Mouse Development. (eds. J. Rossant and P.P.L. Tam), Academic Press. Chapter 16, 331-370.
Discussion Materials:
Rupp PA, Czirok A, Little CD. (2004). Alphavbeta3 Integrin-dependent Endothelial Cell Dynamics in vivo. Development. 2004 Jun;131(12):2887-97.
Gerhardt H, Golding M, Fruttiger M, ... (2003). VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol. 2003 Jun 23; 161(6):1163-77.
Li S, Zhou D, Lu MM, Morrisey EE. (2004). Advanced Cardiac Morphogenesis Does Not Require Heart Tube Fusion. Science Vol(35); 2004 Oct 10; 1619-22.
West GB, Brown JH, Enquist BJ. (1997). A General Model for the Origin of Allometric Scaling Laws in Biology. Science Vol(276); 1997 Apr. 4; 122-126.
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| Session #7: Tissue and Organ Engineering |
Date: Thurs, Nov 3, noon - 2PM |
Guest Faculty: Dr. Abraham Stroock (Department of Chemical Engineering, Cornell University, Ithaca)
Reviews:
Walker GM, Zeringue HC, Beebe DJ. (2004). Microenvironment design considerations for cellular scale studies. Lab Chip. 2004 Apr; 4(2):91-97.
Zimmermann WH, Eschenhagen T. (2003). Cardiac Tissue Engineering for Replacement Therapy. Heart Failure Reviews, 8, 259-269, 2003.
Muschler GF, Nakamoto C, Griffith LG. (2004). Engineering principles of clinical cell-based tissue engineering. J Bone Joint Surg Am. 2004 Jul;86-A(7): 1541-58.
Colton CK. (1995). Implantable biohybrid artificial organs. Cell Transplant. 1995 Jul-Aug;4(4):415-436.
Reading Assignments:
Ng CP, Helm CL, Swartz MA. (2004). Interstitial flow differentially stimulates blood and lymphatic endothelial cell
morphogenesis in vitro. Microvasc Res. 2004 Nov;68(3):258-64.
Stevens MM, Marini RP, Schaefer D, Aronson J, Langer R, Sharstri VP. (2005). In vivo engineering of organs: the bone bioreactor. Proc Natl Acad Sci USA. 2005 Aug 9;102(32):11450-5.
Song JW, Gu W, Futai N, Warner KA, Nor JE, Takayama S. (2005). Computer-controlled microcirculatory support system for endothelial cell culture
and shearing. Anal Chem. 2005 Jul 1;77(13):3993-9.
Levenberg S, Rouwkema J, Macdonald M, Garfein ES, ... (2005). Engineering vascularized skeletal muscle tissue. Nat Biotechnol. 2005 Jul;23(7):879-84.
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| Session #8: Salivary Gland Morphogenesis |
Date: Thurs, Nov 10, noon - 2PM |
Guest Faculty: Dr. Matthew Hoffman (Matrix and Morphogenesis Unit, Craniofacial and Developmental Biology and Regeneration Branch, NIDCR/NIH)
Reviews:
Wang J, Laurie GW . (2004). Organogenesis of the exocrine gland. Development Biology 273 (2004) 1-22.
Eswarakumar VP, Lax I, Schlessinger J. (2005). Cellular signaling by fibroblast growth factor receptors. Cytokine & Growth Factor Reviews 16 (2005) 139-149.
Discussion Materials:
Steinberg Z, Myers C, Heim VM, Lathrop CA, ... (2005). FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis. Development 2005 Mar; 132(6):1223-34.
Sakai T, Larsen M, Yamada KM. (2003). Fibronectin requirement in branching morphogenesis. Nature 2003 Jun 19; 423 (6942):876-81.
Steer DL, Shah MM, Bush KT, Stuart RO, Sampogna RV... (2004). Regulation of ureteric bud branching morphogenesis by sulfated proteoglycans in the developing kidney. Developmental Biology 272 (2004) 310-327. |
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| Session #9: Kidney Morphogenesis |
Date: Thurs, Nov 17, noon - 2PM |
Guest Faculty: Dr. Doris Herzlinger (Department of Physiology and Biophysics, Weill Medical College of Cornell University)
Review:
Yu J, McMahon AP, Valerius MT. Recent genetic studies of mouse kidney development. Curr. Opin. Genet. Dev. 2004 Oct;14(5):550-557.
Primary research Papers:
Basson MA, Akbulut S, Watson-Johnson J, et. al. Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. Dev. Cell. 2005 Feb;8(2):229-239.
Shakya R, Watanabe T, Costantini F. The role of GDNF/Ret signaling in ureteric bud cell fate and branching morphogenesis. Dev. Cell. 2005 Jan;8(1):65-74.
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| Session #10: Gut Morphogenesis |
Date: Thurs, Dec. 1, noon - 2PM |
Guest Faculty: Dr. Didier Stainier (Department of Biochemistry and Biophysics, UCSF)
http://www.ucsf.edu./dyrslab/
Reviews:
Bass AF, Smit L, Clevers H. LKB1 tumor suppressor protein: PARtaker in cell polarity. Trends Cell Biol. 2004 Jun;14(6):312-319.
Le Bivic A. E-cadherin-mediated adhesion is not the founding event of epithelial cell polarity in Drosophila. Trends Cell Biol. 2005 May;15(5):237-240.
Reading Assignments:
Dollar GL, Weber U, Mlodzik M, Sokol SY. Regulation of Lethal giant larvae by Dishevelled. Nature. 2005 Oct 27; 437(7063).
Baas AF, Kuipers J, van der Wel NN, Batlle E, Koerten HK, Peters PJ, Clevers HC. Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell. 2004 Feb;116(3):457-66. |
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| Session #5: Mammary Gland Morphogenesis |
Date: Thurs, Dec 8, noon - 2PM (moderator: Myat) |
Reviews:
Hinck, L. (2004). The versatile roles of "axon guidance" cues in tissue morphogenesis. Dev Cell 7, 783-793.
Shaw, K. R., Wrobel, C. N., and Brugge, J. S. (2004). Use of three-dimensional basement membrane cultures to model oncogene-induced changes in mammary epithelial morphogenesis. J Mammary Gland Biol Neoplasia 9, 297-310.
Hinck L, Silberstein GB. (2005). Key stages in mammary gland development: The mammary end bud as a motile organ. Breat Cancer Res. 2005 Oct 3;7(6):245-251.
Discussion Materials:
Debnath, J., Mills, K. R., Collins, N. L., Reginato, M. J., Muthuswamy, S. K., and Brugge, J. S. (2002). The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell 111, 29-40.
Srinivasan, K., Strickland, P., Valdes, A., Shin, G. C., and Hinck, L. (2003). Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis. Dev Cell 4, 371-382.
Wiseman BS, Sternlicht MD, Lund LR, Alexander CM, Mott J, Bissell MJ, Solowary P, etc. (2003). Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis. J Cell Biol. 2003 Sep 15;162(6):1123-33. |
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